Prognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patients

CD103-positive tissue resident memory-like CD8+ T cells (CD8CD103 TRM) are associated with improved prognosis across malignancies, including high-grade serous ovarian cancer (HGSOC). However, whether quantification of CD8, CD103 or both is required to improve existing survival prediction and all HGSOC patients only specific subgroups benefit from infiltration, remains unclear. To address this question, we applied image-based CD8 multiplex immunohistochemistry in the intratumoral stromal compartments 268 advanced-stage two independent clinical institutions. Infiltration CD8CD103 immune cell subsets was clinicopathological factors. Our results suggest TRM as a superior method for prognostication compared single quantification. A observed treated primary cytoreductive surgery. Moreover, group limited no macroscopic tumor lesions after This approach provides novel insights into prognostic stratification may contribute personalized treatment strategies future.